Docetaxel nephrotoxicity
WebAbstract. Cisplatin is a potent tubular toxin with a high incidence of nephrotoxicity. Carboplatin is considered less nephrotoxic but can still cause tubular injury and interstitial nephritis in patients who have been previously treated with cisplatin. The affected individuals usually have nonoliguric renal failure with a urine output of more ... WebDocetaxel with cisplatin as first-line therapy for advanced NSCLC: Similar survival but increased incidence of diarrhea, infections, peripheral edema, and stomatitis in patients …
Docetaxel nephrotoxicity
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WebNational Center for Biotechnology Information WebDocetaxel and cyclophosphamide (TC) adjuvant chemotherapy for breast cancer [1] This table is provided as an example of how to administer this regimen; there may be other …
WebOct 17, 2024 · bleeding gums blistering, peeling, or loosening of the skin blood in the urine or stools burning, tingling, numbness, or pain in the hands, arms, feet, or legs chest pain chills cough decrease in the amount of urine diarrhea difficulty in swallowing difficulty moving dizziness dry eyes fainting fast, slow, or irregular heartbeat fever heartburn WebJan 25, 2012 · Nephrotoxicity associated with docetaxel is rare (<0.1%). However, tubular nephrotoxicity associated with docetaxel in patients with normal renal function has been reported . Those authors showed that the urinary β2-microglobulin and N-acetyl-β-d-glucosaminidase were increased after docetaxel administration as well as cisplatin. …
WebDocetaxel 75 mg/m 2 immediately followed by cisplatin 75 mg/m 2 IV in repeated 3-week cycles. Dosage Modification for Toxicity IV If nadir platelet count is <25,000/mm 3 or febrile neutropenia or serious nonhematologic toxicity occurs, reduce docetaxel dose to 65 mg/m 2 for subsequent cycles. WebDocetaxel is used to treat: breast cancer; prostate cancer; stomach cancer; head and neck cancer; non-small cell lung cancer (NSCLC). It may sometimes be used to treat …
WebDec 22, 2024 · Nephrotoxicity: In the event of a rise in serum creatinine ≥grade 2 (>1.5 × normal value) despite adequate rehydration, CrCl should be determined before each subsequent cycle and the following dose reductions should be considered ... (20 mg docetaxel/mL) with a calibrated syringe and inject via a single injection ...
WebJan 3, 2024 · All of these drugs can affect the glomerulus, tubules, interstitium, or renal microvasculature via different mechanisms, with clinical manifestations that range from an asymptomatic elevation of serum creatinine and electrolyte disorders to acute … rebel vs shelly martinezWebDocetaxel (Taxotere, Docefrez) is a medication prescribed primarily for the treatment of breast cancer. Docetaxel is also a second-line treatment for patients with non-small cell … rebel victoryWebSep 28, 2024 · Docetaxel Injection is indicated for the treatment of patients with locally advanced or metastatic breast cancer after failure of … rebel violet clothingWebJul 15, 2024 · Classes of chemotherapies that cause hepatotoxicity include the antitumor antibiotics, alkylating agents, platinum agents, antimetabolites, antimicrotubular agents, … rebel walls discountWebSep 6, 2024 · Chemotherapeutic agents, also referred to as antineoplastic agents, are used to directly or indirectly inhibit the uncontrolled growth and proliferation of cancer cells. They are classified according to their mechanism of action and include alkylating agents , antimetabolites , topoisomerase inhibitors , antibiotics, mitotic inhibitors, and rebel walls.frWebFeb 21, 2024 · Cisplatin nephrotoxicity; Clinical manifestations, diagnosis, and treatment of anthracycline-induced cardiotoxicity ... et al. Phase II study of docetaxel for recurrent or metastatic non-small-cell lung cancer. J Clin Oncol 1994; 12:1238. Francis P, Schneider J, Hann L, et al. Phase II trial of docetaxel in patients with platinum-refractory ... rebel vs shadowWebSep 15, 2024 · The mechanisms of doxorubicin cardiotoxicity are necrosis and apoptosis of cardiac myocytes followed by myocardial fibrosis. 1 Doxorubicin-induced cardiotoxicity involves several processes, such as the formation of iron-dependent oxygen free radicals and peroxidation of lipids in the membrane of myocardial mitochondria, that lead to … university of pennsylvania health system npi